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Our Journey - Sekkei Bio

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  • contact@sekkeibio.com

Our Journey

Welcome to Sekkeibio

Driving Innovation in Drug Discovery

We started with the idea of establishing an innovation driven drug discovery organization in India. We are passionate about contributing towards addressing global unmet need. We received BIRAC Ignition Grant (BIG) in support of rationally designing novel insulin analogues conducive for oral delivery. The program enabled development of in-silico platform, Sq-PROT, our proprietary peptide & protein design tool that allows multi-parametric ligand design.
Scientist in ppe suit placing a slide on specimen stage of a laboratory microscope making adjustments. Chemist in coverall working with various bacteria, tissue blood samples for antibiotics research
diabetic-person-checking-their-glucose-level
We have shortlisted three novel insulin lead candidates that are tolerant to gut enzyme degradation and found to be activite in mice and rats. A successful oral basal insulin will improve patient convenience and help early initiation of Insulin therapy, thus changing the treatment paradigm.  It will be an important option for treatment of hypergycemia in Patients with Type 1 diabetes, Type 2 diabetes and cystic fibrosis.
To address the current ongoing epidemic related to opioid analgesics, and find effective therapy  for diabetic neuropathy, we have designed a peptide non-opiate analgesic that targets multiple receptors. We have selected lead candidates active against all three targets with >1000-fold selectivity to the off-targets with considerable analgesic effects in animals. Use of Sq-PROT enables design of multi-targeted ligands and reduces cost & time of discovery.
Today, we have extended our research interests beyond small molecule and biologics to RNA therapeutics. We are building a circular mRNA platform as circular mRNA represents the most promising route to building next generation, cost-effective vaccines and drugs.
3d-representation-dna

Our Journey

2017
  • BIRAC Ignition Grant (BIG) received
  • Operations established at CCAMP, Bangalore
2018
  • Small molecules design platform Sq-SYNT establishedProtein/peptide design platform Sq-PROT initiated .
  • Pichia expression system established
2019
  • Operations established at IITM Bioincubator Chennai.
2020
  • Protein/peptide design platform Sq-PROT established.
2021
  • Linear mRNA technology established.
  • Animal PoC (efficacy) obtained for first gen insulin and non-opiate analgesic.
  • Money raised to (seed round) $200,000. ($2 mil) USD raised as Part of Series-A.
2022
  • Circular mRNA technology established.
  • Publication-: Mapping Structural Drivers of Insulin Recognition and Specificity Using Molecular Dynamics and Free Energy Calculations.
  • Enzyme design established.
2017
  • Incorporation
  • INR (₹)5M Grant Received from BIRAC
2018
  • Pichia expression system established
  • Sq SYNT established for small molecule design
2019

  • Sq PROT established For biologics design

2020

  • Animal Proof of concept for novel biologics demonstrated

2021
  • $2.0 M raised as part of Series A
  • Linear mRNA technology established
2022

  • Proprietary circular RNA technology established

  • Monoclonal antibody delivered as RNA in human cells

2023
  • Funded programs by Bill & Melinda Gates Foundation
  • Provisional filed for circular RNA
2024
And Beyond
  • Collaboration established with pharma for oral incretin development
  • PCT application filed for Circular RNA

Quick Links

Learn More

Support

  • Sekkei Bio Private Limited
    Floor 3, IITM Bio-incubator, IIT Madras Research Park, Kanagam Road, Taramani, Chennai-600113, INDIA
  • contact@sekkeibio.com
  • 080-40157612
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